Originally Posted by
The Atheist
Are you sure about that?
All I've seen are claims that they had the reaction very soon afterwards, which would make sense.
I'm sure that's what I read in the report on these reactions. The issue of the epipens is being conflated with the actual reactions these people had.
From your link:
Quote:
Anaphylactoid reactions with Pfizer/BioNTech COVID-19 vaccine: pharmacovigilance perspective and public information needs
Remember that post from Planigale painstakingly describing the difference (with way more detail than necessary and I see hypersensitivity reactions described as allergic on a regular basis) between anaphylaxis and anaphylactoid reactions?
The article says:
Quote:
These individuals developed symptoms of anaphylactoid reaction shortly after receiving the vaccine.
But they don't define "shortly after." It was the next day. I know that was in the report but I'll have to find it again.
The article explains the two kinds of reactions calling them both allergic reactions.
Quote:
Anaphylaxis is an allergic response by the body to external substances such as food, medicines and vaccines. The manifestations of anaphylaxis include effects on the cardiovascular, respiratory, gastrointestinal systems and the skin by way of severe rash. The blood pressure can drop, and breathing can become difficult.
“Treatment is with injectable adrenalin and later with corticosteroids and other supporting measures. Anaphylaxis is well known to occur with some food substances such as peanuts. This is why people who get vaccinated are asked to stay in the place of vaccination for a while to be monitored because anaphylaxis occurs early.
“However, the events that appear to have occurred after the Pfizer vaccine in two people were anaphylactoid reactions, which are allergic reactions that share some of the characteristics of anaphylaxis but are less severe. Prompt treatment was given.
“Both anaphylaxis and anaphylactoid and other allergic reactions are more likely to occur in people who have previous history to allergies.
A simple explanations without a lot of clutter:
Quote:
Anaphylaxis involves a type of antibody called IgE which recognises a specific allergen and triggers the release of chemicals from immune cells on exposure to that allergen. Anaphylactoid reactions trigger the same responses as anaphylaxis but do not involve IgE antibodies.”
I did find with more searching that both reactions can occur right away or later. There is a lot of good information in this article (though it is also very cluttered
) :
NIH: A Reliable Method for the Evaluation of the Anaphylactoid Reaction Caused by Injectable Drugs They do use guinea pigs and nude rats for the model.