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Old 26th November 2021, 12:38 PM   #11
Louden Wilde
Critical Thinker
Join Date: Oct 2020
Location: NYC
Posts: 380
Originally Posted by d4m10n View Post
Can you be more specific as to referent of the highlighted word?

Seems to me that the gamete binary accounts for > 99% of live births, that is, people who are born with oocytes or on a developmental pathway to produce sperm. The remaining fraction of a percent are the subject of this thread, and a fascinating subject in and of itself, quite apart from "judgements humans as a society have made on how each sex looks and behaves." I was surprised to learn (for example) that individuals with de la Chapelle syndromeWP may be fully masculinized due to the presence of an anomalous SRY gene, despite being genetically 46,XX.
But note folks with this syndrome are sterile (so it's still definitely a DSD) - likely due to incompatibilities between X chromosome inactivation in mammals and being a functional male. There are rodents (notably genus Tokudaia - "spiny rats") that lack a Y Chom and mostly SRY, but they are X/0. Note the main function of the SRY protein is to trigger expression of a related gene/protein, Sox9 that subsequently starts the male developmental cascade - these rodents have a Sox9 gene, but it does not respond to SRY protein
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