The opioid epidemic

Minoosh

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I'm starting this thread on a huge topic because it keeps getting brought up in the painful process of passing a hopefully halfway decent health-care bill.

Here is my main question, and it's medical, not political: If billions are dedicated solely to treatment for opioid dependency, what does the solution look like?

The last Senate iteration provided those billions, but then slashed Medicaid, which providers said would make it much harder for addicts to get appropriate treatment.

This NBC story gets into some of the nitty-gritty, and there are plenty of other links I could provide, but almost any comprehensive media report can provide the basic of the issue. What I want to know what the infrastructure of this care would look like, and what ideological battles might have to be fought. Statistics for recovery from opioid dependency aren't great for full-blown addicts. Some studies indicate a 91 percent relapse rate. People who got into using for relief of physical pain can be detoxed fairly straightforwardly, but the problem is much tougher when people are using opioids to treat emotional pain such as depression over job loss and general hopelessness. For some the best option might be lifelong maintenance with methadone or Suboxone. Methadone is a problem because it can be diverted, and because huge tolerances encourage higher doses which become dangerous as take-home doses get diverted, as some will. Suboxone is safer, and effectively blocks the effect of stronger opioids, but there are issues. You must already be in withdrawal before it is safe to give Suboxone. And quite frankly, IMO, its effects are not as euphoric as other opioids, including methadone, which is also cheaper. It can, though, provide other advantages that make up for the loss of euphoria.

If we had triage for opioid addicts, what would that look like? People being detoxed with the old 30-day inpatient stay? People on outpatient counseling and replacement therapy? People directed to faith-based abstinence programs, which do actually work for some? Those are very cheap, actually free for the most part, but they're not for everyone. All IMO would need a strong emphasis on relapse prevention, a lot of education and possibly support groups.

We've had this perfect storm of cheap heroin, opportunistic marketing of OxyContin, which once had a 160 mg pill - that is the equivalent of *32* Percocet - which killed quite a few people because crushed up and snorted, that would be a lethal dose for quite a few people. Adulteration with fentanyl and carfentanil has caused many deaths. You can die just handling carfentanil. IMO another problem is that widespread use of hydrocodone, which became a substitute for codeine, turned out to be more addictive than codeine and was upgraded to Schedule II status, probably belatedly.

This is such a complex and seemingly intractable problem that I'm wondering how effective even top-notch medical care is when the continued temptation of chemical relief is easily fulfilled and can put addicts back at square one in a hurry.

Should treatment aim at abstinence or harm reduction, two philosophies that can sometimes clash? I just don't know and am interested in hearing other people's thoughts. I've even wondered if things will just dissipate on its own, as the human cost of addiction becomes glaring enough. Not too confident on that last bit.
 
tl;dr bump:

How to rationally apportion anti-opioid crisis funding in light of the notorious difficulties in even finding out "what works." Nothing works all that well. Ideological battles also a stumbling block.
 
Start by reducing the number of prescriptions.

More than 259 million opioid prescriptions were written in 2012.

1.9 million Americans are addicted to opioid painkillers.

The U.S. makes up 4.6 percent of the world’s populations but
consumes 81 percent of the world supply of oxycodone.

4.3 million adolescents and adults reported non-medical use
of prescription opioids in 2014.

4 out of 5 heroin users started on prescription opioids.

http://www.nsc.org/RxDrugOverdoseDocuments/Prescription-Nation-2016-American-Drug-Epidemic.pdf
 
Start also by continuing the trend of making Narcan/Naloxone available in non-medical settings - police officers, fire personnel, lots of other people should be able to carry the stuff.

Start by strongly shifting treatment to a more medical science approach, instead of 12-step, boot camps, or other behavior/discipline based approaches - those have been shown to have much worse success rates than medical approaches - almost as bad as no treatment at all. We need to strongly get away for our cultural aversion to using actual medicine to treat addiction.

Work with employers to tease out how to manage addiction and treatment with stable jobs. You don't want employers saddled with drug addicts who are unreliable and dangerous to work with - but you don't want to fire everyone who is genuinely going through treatment, making the effort, but has an occasional relapse. That's a very hard balance.
 
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Start also by continuing the trend of making Narcan/Naloxone available in non-medical settings - police officers, fire personnel, lots of other people should be able to carry the stuff.
Agree. Addicts live to fight another day.

Start by strongly shifting treatment to a more medical science approach, instead of 12-step programs. We need to strongly get away for our cultural aversion to using actual medicine to treat addiction.
Also agree, but with a caveat. If someone already has faith in a god, that faith may be a legitimate resource. Include that in triage protocol?

Work with employers to tease out how to manage addiction and treatment with stable jobs. You don't want employers saddled with drug addicts who are unreliable and dangerous to work with - but you don't want to fire everyone who is genuinely going through treatment, making the effort, but has an occasional relapse. That's a very hard balance.
Good opening for cognitive-behavioral treatment. Jobs are very important motivators. The satisfaction of work and the sense of community it builds are decent armor against relapse triggers.
 
Also agree, but with a caveat. If someone already has faith in a god, that faith may be a legitimate resource. Include that in triage protocol?

Sure - my statement was maybe overly strong. Part of the problem is that many such programs actively discourage or prohibit the use of methadone, suboxone, or other medicines to manage the physical aspects of addiction or withdrawl. Medicine can be very helpful, but many behavior modification programs won't allow addicts in unless they stop using ANY opiodes, including methadone or suboxone.

Medicine plus cognitive therapy is great - more cognitive therapy people need to get over the aversion to methadone and suboxone.

12-Step with no medicine works for a few, but has a very low success rate and generally discourage the use of medical based approaches with better success rates. Boot camps and other discipline approaches are rife with abuse (when the addict is a minor) - they might get the person clean, in great shape, and motivated, but have very high relapse rates once the people leave the program to return to their lives.
 
12-Step with no medicine works for a few, but has a very low success rate and generally discourage the use of medical based approaches with better success rates.
There's a decent workaround if subjects respond to a 12-step approach and have alcohol problems: Go to AA for support abstaining from alcohol. The other meds are "outside issues." Nobody has to know about them. Medically managed opiate replacement therapy (assuming compliance) is a world away from heroin abuse. You can share with people who understand that.

Boot camps and other discipline approaches are rife with abuse (when the addict is a minor) - they might get the person clean, in great shape, and motivated, but have very high relapse rates once the people leave the program to return to their lives.
Relapse is a bitch. I've seen young moms do everything right to get their kids back - then get sucked right back in once agencies are no longer tracking them. Is there a role for a kind of extended "probation" to provide additional support?
 
There's a decent workaround if subjects respond to a 12-step approach and have alcohol problems: Go to AA for support abstaining from alcohol. The other meds are "outside issues." Nobody has to know about them.

Yeah but the thing is that 12-step programs discourage the use of medecine because in the end you rely on a "higher power" to solve the issue for you.
 
Medicinal marijuana can help in two ways:

1. It can be used to treat chronic pain.

2. It can be used to treat drug addiction.
 
Medicinal marijuana can help in two ways:

1. It can be used to treat chronic pain.

2. It can be used to treat drug addiction.

There is truth in what TruthJonsen says - at least, it is starting to look that way.

As the legal and social stigma around marijuana fades, we should start to get much more science done with pot. It could be a game changer.
 
Yeah but the thing is that 12-step programs discourage the use of medecine because in the end you rely on a "higher power" to solve the issue for you.
Certainly there are individuals who are very opinionated about the use of medication, but really, that's on the wane. There are many others who rely on medication for "outside issues." I think there's probably more humility about that than you think.

I'm saying, if someone is already a person of faith or on the bubble, the friendships, prayers and emotional "work" that takes place will be effective for some people.

Russell Brand is one who has been very opinionated about "abstinence-based recovery" and opposed to "parking" people on methadone. He doesn't mention a "higher power," probably deliberately. That's an ideological position essentially rejecting "harm reduction," which I think is a kind of arrogant line to push. Like I said, 12-step not for everybody - and IMO opiate replacement therapy, for life if necessary, may be necessary for certain people. It's not a public-health problem, as long as those meds don't end up for sale on the street.
 
Medicinal marijuana can help in two ways:

1. It can be used to treat chronic pain.

2. It can be used to treat drug addiction.
There's another legal substance that chronic pain patients are using instead of Rx or street opiates. It too can be addictive, but ODs are almost unheard of. The DEA wanted to place it in Schedule I (no medical use whatsoever and very little research), but there was quite a lot of opposition to the move and for now it remains legal.

Marijuana should not be a Schedule I drug. That's stupid. It really is impossible to OD. The federal designation IMO puts state programs in jeopardy.

ETA:
There is truth in what TruthJonsen says - at least, it is starting to look that way.

As the legal and social stigma around marijuana fades, we should start to get much more science done with pot. It could be a game changer.
IMO the prohibition mindset and shame factors have proved to be horrendously harmful to public health. Part of the U.S. temperance legacy.

One barrier I see to federal acceptance is that botanicals do not fit the FDA model of medication - they are not powders consisting of one active ingredient. But there are ways to standardize the products in order to carry out sound research and responsible dispensing.
 
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Start also by continuing the trend of making Narcan/Naloxone available in non-medical settings - police officers, fire personnel, lots of other people should be able to carry the stuff.

Start by strongly shifting treatment to a more medical science approach, instead of 12-step, boot camps, or other behavior/discipline based approaches - those have been shown to have much worse success rates than medical approaches - almost as bad as no treatment at all. We need to strongly get away for our cultural aversion to using actual medicine to treat addiction.

Work with employers to tease out how to manage addiction and treatment with stable jobs. You don't want employers saddled with drug addicts who are unreliable and dangerous to work with - but you don't want to fire everyone who is genuinely going through treatment, making the effort, but has an occasional relapse. That's a very hard balance.
The creeps that made the Epipen version of Narcan cost $3000/dose should be drawn and quartered.

Back in the day when there was an amphetamine epidemic, Nixon made the legal versions of the drug near impossible to get. The epidemic subsided.

The DEA/FDA have cracked down on pain med prescriptions. I have prescriptive authority for class 3 to 5 drugs but I've never used it. It's not something I use in my practice. But I am familiar with changes in the law. Not long ago a new law was passed in WA State but I think it might be federal. If I prescribe any scheduled drugs, including class 5 drugs I think, I have to send in a monthly report of the patients I prescribed them for. Pharmacies have to do the same for patients they dispensed any scheduled drugs to.

Then the pharmacy board cross checks the list to find any patient getting drugs from more than one doctor. They will also be monitoring patient drug use.

It's a good first step.

The new additions to the problem are the designer drugs coming in from other countries like the altered versions of fentanyl. That is not something I am familiar with so I defer to other forumites.

I agree with cresent about evidence based, not religious based treatment with one exception, if there is evidence it is successful, keep it, religion based or not. Having worked with drug addicted persons in the past, I know there is no one size fits all.
 
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As for marijuana use, Sessions can go to hell. The old white guys in the federal government and many people in law enforcement need to get over it. They have been indoctrinated to believe pot is a narcotic. Let it go.

Deal with meth and opiate problems first. Alcoholism is also up there on the priority list. Stop wasting resources on pot and if it keeps people off other drugs, that's a good thing.
 
"Start also by continuing the trend of making Narcan/Naloxone available in non-medical settings - police officers, fire personnel, lots of other people should be able to carry the stuff."

We are starting Narcan training this week.
 
I've often wondered how many of those were actually financed by Medicare and Medicaid.

It's too bad that this could also make it harder for people with legitimate chronic pain. Thanks, I'll take a look at this.

Fortunately, narcotics turn out to be a crappy treatment for chronic pain.
After chronic opioid use, tolerance makes the effective dose ever increasing until some unfortunate patients end up on unbelievably huge daily doses (lethal for an opioid naive person). The nervous system adapts to the opioid saturation by essentially turning up the gain in the pain pathways, making these people extremely sensitive to small painful stimuli. As you can imagine this ends up making their chronic pain ever more difficult to manage.
Its really not a good situation, although in a few cases there are no other good options.

When I trained in medicine in the late 1990's we were all taught that pain was being inadequately treated across the board, and were encouraged to be generous with the meds to make sure patients pain was adequately controlled. I was also taught that when used for an acute painful condition (a broken arm for instance) that potential opioid addiction should not be a big concern and it was more important to adequately treat the pain.
As we can all see this advice has turned out to be problematic. Definitely part of the solution to the current epidemic is to reduce prescriptions, and DO be concerned about addiction.

Interestingly, a family member of mine in Japan has recently had surgery on his fractured wrist, involving a titanium plate and screws, and he was prescribed NO opioids whatsoever, because the Japanese physicians do worry about addiction, and do NOT use opioids for acute pain.
 
There's another legal substance that chronic pain patients are using instead of Rx or street opiates. It too can be addictive, but ODs are almost unheard of. The DEA wanted to place it in Schedule I (no medical use whatsoever and very little research), but there was quite a lot of opposition to the move and for now it remains legal.

Marijuana should not be a Schedule I drug. That's stupid. It really is impossible to OD. The federal designation IMO puts state programs in jeopardy.

ETA:
IMO the prohibition mindset and shame factors have proved to be horrendously harmful to public health. Part of the U.S. temperance legacy.

One barrier I see to federal acceptance is that botanicals do not fit the FDA model of medication - they are not powders consisting of one active ingredient. But there are ways to standardize the products in order to carry out sound research and responsible dispensing.

https://www.washingtonpost.com/news...ew-racial-justice-bil/?utm_term=.53eba79de182
 
The creeps that made the Epipen version of Narcan cost $3000/dose should be drawn and quartered.

Back in the day when there was an amphetamine epidemic, Nixon made the legal versions of the drug near impossible to get. The epidemic subsided.

The DEA/FDA have cracked down on pain med prescriptions. I have prescriptive authority for class 3 to 5 drugs but I've never used it. It's not something I use in my practice. But I am familiar with changes in the law. Not long ago a new law was passed in WA State but I think it might be federal. If I prescribe any scheduled drugs, including class 5 drugs I think, I have to send in a monthly report of the patients I prescribed them for. Pharmacies have to do the same for patients they dispensed any scheduled drugs to.

Then the pharmacy board cross checks the list to find any patient getting drugs from more than one doctor. They will also be monitoring patient drug use.

It's a good first step.

The new additions to the problem are the designer drugs coming in from other countries like the altered versions of fentanyl. That is not something I am familiar with so I defer to other forumites.

I agree with cresent about evidence based, not religious based treatment with one exception, if there is evidence it is successful, keep it, religion based or not. Having worked with drug addicted persons in the past, I know there is no one size fits all.

My stupid state is having trouble with this most basic first step!!!
http://www.govtech.com/policy/Missouri-Statewide-Prescription-Drug-Monitoring-Bill-Founders.html

With regard to heroin and Fentanyl, according to this data:

https://www.asam.org/docs/default-source/advocacy/opioid-addiction-disease-facts-figures.pdf

...4 out of 5 iv drug addicts started out using prescription painkillers and "94% of respondents in a 2014 survey of people in treatment for opioid addiction said they chose to use heroin because prescription opioids were “far more expensive and harder to obtain.”9"

In other words you are probably correct, stopping the flow of prescription pain pills from the pharmacies would likely go a long way to stemming the epidemic.

Of course the current addicts will still need treatment.
 
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Fortunately, narcotics turn out to be a crappy treatment for chronic pain.
After chronic opioid use, tolerance makes the effective dose ever increasing until some unfortunate patients end up on unbelievably huge daily doses (lethal for an opioid naive person). The nervous system adapts to the opioid saturation by essentially turning up the gain in the pain pathways, making these people extremely sensitive to small painful stimuli. As you can imagine this ends up making their chronic pain ever more difficult to manage.
Its really not a good situation, although in a few cases there are no other good options.


snip...

Have to ask "evidence for this"?

I'm asking because it is totally outside my experience with chronic pain. I've been taking opiate based painkillers for the majority of my life (going on 35 years now). My dosage has not needed to be increased over that time, I do now use another drug for pain relief as well but that is for a different kind of chronic pain (neuropathic caused by the deterioration in my spine) for which opiate based painkillers are not very good at treating.

The problem seems to be more based on people not getting the right type of treatment in the first place and their conditions being badly managed by their primary medical treatment giver.
 
Have to ask "evidence for this"?

I'm asking because it is totally outside my experience with chronic pain. I've been taking opiate based painkillers for the majority of my life (going on 35 years now). My dosage has not needed to be increased over that time, I do now use another drug for pain relief as well but that is for a different kind of chronic pain (neuropathic caused by the deterioration in my spine) for which opiate based painkillers are not very good at treating.

The problem seems to be more based on people not getting the right type of treatment in the first place and their conditions being badly managed by their primary medical treatment giver.

Yes, I agree, and I am happy to here that you are not having these difficulties. It sounds like your pain is being well managed.

The evidence that opioids are effective for managing chronic pain is poor, because there are no long term controlled studies.
The evidence of potential for harm from opioids is robust.
http://annals.org/aim/article/20893...opioid-therapy-chronic-pain-systematic-review
"Conclusion:
Evidence is insufficient to determine the effectiveness of long-term opioid therapy for improving chronic pain and function. Evidence supports a dose-dependent risk for serious harms."

http://jamanetwork.com/journals/jama/fullarticle/2503508
"Of primary importance, nonopioid therapy is preferred for treatment of chronic pain. Opioids should be used only when benefits for pain and function are expected to outweigh risks."

In this study "We found that 49% of patients taking opioids continued to report severe pain (≥ 7/10)."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960717/

Opioid induced hyperalgesia is a documented phenomenon.
http://www.sciencedirect.com/science/article/pii/S1526590008008018

My own experience comes from managing patients with chronic pain who come for repeat back surgery, etc. These patients may already take 60, 90, or 120 mg of Morphine equivalents per day. I am able to dose these individuals with enough IV Fentanyl (500-1500mcg) to kill an opioid naive patient while they remain awake, talking, with very little effect. These same individuals are paradoxically extremely sensitive to painful stimuli, and present a very difficult problem in post operative pain management. They may require 10 times the standard opioid dose to manage, and most nurses and physicians are not comfortable administering or prescribing those dosages.

This says nothing about what percentage opioid treated chronic pain patients have these difficulties. I only see the people with ongoing problems serious enough to warrant surgery, so it is a biased sample, for sure.
 
I have limited knowledge and understanding of the present opioid epidemic. But something vaguely relevant to keep in mind: Untreated pain itself causes significant adverse health effects. My understanding is that the mortality associated with the present epidemic has been partly due to the flooding of street markets with fentayl and carfentanil - particularly powerful and lethal opioids; which are particularly dangerous when obtained in unpredictable concentrations. (And in at least one case, fentanyl being passed off on the street as the much less potent and dangerous Norco).
 
As to opioids, many abusers got that way because they were prescribed them for pain. So they then get prosecuted because of what was done to them (made them adicts)....
For the record, having worked with drug users in the past and admitting I don't have current information, almost every narcotic drug abuser will tell you this whether it is true or not.

They also tend to blame PTSD. We had a saying, that guy was born in Vietnam. It meant that the person denied anything prior had anything to do with their alcoholism or drug abuse. But statistics don't corroborate the claims.

Not saying over-prescribing hasn't contributed, mind you, just that the numbers are probably inflated.
 
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Yes, I agree, and I am happy to here that you are not having these difficulties. It sounds like your pain is being well managed.

The evidence that opioids are effective for managing chronic pain is poor, because there are no long term controlled studies.
The evidence of potential for harm from opioids is robust.
http://annals.org/aim/article/20893...opioid-therapy-chronic-pain-systematic-review
"Conclusion:
Evidence is insufficient to determine the effectiveness of long-term opioid therapy for improving chronic pain and function. Evidence supports a dose-dependent risk for serious harms."

http://jamanetwork.com/journals/jama/fullarticle/2503508
"Of primary importance, nonopioid therapy is preferred for treatment of chronic pain. Opioids should be used only when benefits for pain and function are expected to outweigh risks."

In this study "We found that 49% of patients taking opioids continued to report severe pain (≥ 7/10)."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960717/

Opioid induced hyperalgesia is a documented phenomenon.
http://www.sciencedirect.com/science/article/pii/S1526590008008018

My own experience comes from managing patients with chronic pain who come for repeat back surgery, etc. These patients may already take 60, 90, or 120 mg of Morphine equivalents per day. I am able to dose these individuals with enough IV Fentanyl (500-1500mcg) to kill an opioid naive patient while they remain awake, talking, with very little effect. These same individuals are paradoxically extremely sensitive to painful stimuli, and present a very difficult problem in post operative pain management. They may require 10 times the standard opioid dose to manage, and most nurses and physicians are not comfortable administering or prescribing those dosages.

This says nothing about what percentage opioid treated chronic pain patients have these difficulties. I only see the people with ongoing problems serious enough to warrant surgery, so it is a biased sample, for sure.

Chronic pain management has a lot of issues, anticipatory pain being a well known phenom that is consistent with self reported pain being high despite treatment. It's a function of addiction, not necessarily of the lack of effectiveness of narcotics for pain relief.

I don't disagree, narcotics for chronic pain is not the best choice. Chronic pain needs to be managed by specialists that understand anticipatory pain and drug seeking behavior and they need to use other treatment modes. But that's no reason to quit using narcotics altogether.
 
When I trained in medicine in the late 1990's we were all taught that pain was being inadequately treated across the board, and were encouraged to be generous with the meds to make sure patients pain was adequately controlled. I was also taught that when used for an acute painful condition (a broken arm for instance) that potential opioid addiction should not be a big concern and it was more important to adequately treat the pain.
That was when Pharma Purdue was pushing the line that OxyContin was less addictive than immediate-release oxycodone. Eventually it was found guilty of criminal charges.
Interestingly, a family member of mine in Japan has recently had surgery on his fractured wrist, involving a titanium plate and screws, and he was prescribed NO opioids whatsoever, because the Japanese physicians do worry about addiction, and do NOT use opioids for acute pain.
I have heard opioids are not great for bone pain.

Also knew a doc who considered opioids horrible choices for treating chronic pain. He felt they inevitably made the problem worse.
 
The problem seems to be more based on people not getting the right type of treatment in the first place and their conditions being badly managed by their primary medical treatment giver.
I suspect the UK's prescribing practices are much more rational than those in the U.S.
 

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