IS Forum
Forum Index Register Members List Events Search Today's Posts Mark Forums Read Help

Go Back   International Skeptics Forum » General Topics » Science, Mathematics, Medicine, and Technology
 


Welcome to the International Skeptics Forum, where we discuss skepticism, critical thinking, the paranormal and science in a friendly but lively way. You are currently viewing the forum as a guest, which means you are missing out on discussing matters that are of interest to you. Please consider registering so you can gain full use of the forum features and interact with other Members. Registration is simple, fast and free! Click here to register today.
Reply
Old 30th November 2022, 03:32 AM   #1
Darat
Lackey
Administrator
 
Darat's Avatar
 
Join Date: Aug 2001
Location: South East, UK
Posts: 106,871
Headline: Alzheimer's drug lecanemab hailed as momentous breakthrough

https://www.bbc.co.uk/news/health-63749586

What a nice piece of positive news -
Quote:
One of the world's leading researchers behind the whole idea of targeting amyloid 30 years ago, Prof John Hardy, said it was "historic" and was optimistic "we're seeing the beginning of Alzheimer's therapies". Prof Tara Spires-Jones, from the University of Edinburgh, said the results were "a big deal because we've had a 100% failure rate for a long time".
...snip....

Lecanemab is an antibody - like those the body makes to attack viruses or bacteria - that has been engineered to tell the immune system to clear amyloid from the brain.

Amyloid is a protein that clumps together in the spaces between neurons in the brain and forms distinctive plaques that are one of the hallmarks of Alzheimer's.

...snip...
I'm sure most of us older folk will know of family or friends that have been struck down by Alzheimer's. Hopefully this will only be the start of effective treatments.
__________________
I wish I knew how to quit you

Last edited by Darat; 30th November 2022 at 03:32 AM. Reason: 's
Darat is offline   Quote this post in a PM   Nominate this post for this month's language award Copy a direct link to this post Reply With Quote Back to Top
Old 30th November 2022, 04:57 AM   #2
Jack by the hedge
Safely Ignored
 
Jack by the hedge's Avatar
 
Join Date: Oct 2009
Posts: 14,074
It's very welcome news. Even if the effect of this treatment is only a modest slowing of the rate of progress, it's a remarkable achievement and as you say I hope it's only the start.
Jack by the hedge is offline   Quote this post in a PM   Nominate this post for this month's language award Copy a direct link to this post Reply With Quote Back to Top
Old 30th November 2022, 05:33 AM   #3
Mike!
Official Ponylandistanian National Treasure. Respect it!
 
Mike!'s Avatar
 
Join Date: May 2010
Location: Ponylandistan! Where the bacon grows on trees! Can it get any better than that? I submit it can not!
Posts: 48,749
My wife's grandfather had Alzheimer's and it was heartbreaking. I never knew him beforehand, only the shell of a man he became. He would sit in the corner of her mothers living room asking, "Why are you people keeping me here against my will? Why are you doing this to me?" If he got out on his own he'd walk a few blocks to the house he'd lived in half a century earlier. "My key doesn't work and they said I don't live here."
Another friends father had it and one day he wandered off and has never been seen again.
So here's hoping this turns out to be a major breakthrough treatment.
__________________
"Never judge a man until you’ve walked a mile in his shoes...
Because then it won't really matter, you’ll be a mile away and have his shoes."
Mike! is offline   Quote this post in a PM   Nominate this post for this month's language award Copy a direct link to this post Reply With Quote Back to Top
Old 30th November 2022, 06:15 AM   #4
erlando
Master Poster
 
erlando's Avatar
 
Join Date: Apr 2007
Posts: 2,358
Alzheimer's runs in my mother's family. I have one of the two genes that purportedly are "trigger genes" for Alzheimer's. That's why one of my greatest fears is to get afflicted with Alzheimer's.

I am hopeful that this breakthrough is the start of effective treatments of Alzheimer's.
__________________
"If it can grow, it can evolve" - Eugenie Scott, Ph.D Creationism disproved?
Evolution IS a blind watchmaker
erlando is offline   Quote this post in a PM   Nominate this post for this month's language award Copy a direct link to this post Reply With Quote Back to Top
Old 30th November 2022, 06:16 AM   #5
casebro
Penultimate Amazing
 
casebro's Avatar
 
Join Date: Jun 2005
Posts: 19,672
The old man/ friend a couple doors down has just had his drivers license pulled....

His son got him an Apple watch w/ GPS. He does wear it every day, so far.

I wonder if they can engineer something to dissolve the calcium deposits I have in my arteries, veins, valves, joints....
__________________
Any sufficiently advanced idea is indistinguishable from idiocy to those who don't actually understanding the concept.
casebro is offline   Quote this post in a PM   Nominate this post for this month's language award Copy a direct link to this post Reply With Quote Back to Top
Old 30th November 2022, 10:22 AM   #6
Chris_Halkides
Penultimate Amazing
 
Chris_Halkides's Avatar
 
Join Date: Dec 2009
Posts: 10,945
previous failures

In September medicinal chemist Derek Lowe wrote, "At the same time, though, news like this needs to be examined carefully. As the world knows, the anti-amyloid clinical landscape for Alzheimer's is absolutely littered with failures in every direction: anti-amyloid antibodies of various types, attempts to inhibit beta-secretase and gamma-secretase enzymes, attempts to prevent aggregation, you name it. Nothing has worked. The presumption at this point is that such therapies will not succeed, so if lecanemab has indeed worked, the question is what makes it different. There's a ready answer (up to a point) because antibodies can indeed be quite different (that's their point!) and if you do manage to hit exactly what needs to be hit, you could expect efficacy when apparently similar attempts have led to nothing."

Dr. Lowe indicated that he would return to this topic when more data were made available, which was originally thought to be in November.
__________________
It is possible both to be right about an issue and to take oneself a little too seriously, but I would rather be reminded of that by a friend than a foe. (a tip of the hat to Foolmewunz)
Chris_Halkides is offline   Quote this post in a PM   Nominate this post for this month's language award Copy a direct link to this post Reply With Quote Back to Top
Old 30th November 2022, 07:28 PM   #7
casebro
Penultimate Amazing
 
casebro's Avatar
 
Join Date: Jun 2005
Posts: 19,672
Some recent reading indicated that the amyloid theory was wrong. The the original researcher fibbed about his findings to improve awareness or some such. So amyloid treatments may not be the silver bullet for Alzheimer's.
__________________
Any sufficiently advanced idea is indistinguishable from idiocy to those who don't actually understanding the concept.
casebro is offline   Quote this post in a PM   Nominate this post for this month's language award Copy a direct link to this post Reply With Quote Back to Top
Old 1st December 2022, 08:48 AM   #8
bobdroege7
Illuminator
 
bobdroege7's Avatar
 
Join Date: May 2004
Posts: 3,605
Originally Posted by casebro View Post
Some recent reading indicated that the amyloid theory was wrong. The the original researcher fibbed about his findings to improve awareness or some such. So amyloid treatments may not be the silver bullet for Alzheimer's.
We don't talk about that on our conference calls.

Redundant analytical equipment for testing Flutemetamol, or known by its commercial name Vizamyl, is my gig. A drug used for PET scans to monitor the plaques.

Things are quiet, a dose here, a dose there, supposed to pick up soon.
__________________
Un-american Jack-booted thug

Graduate of a liberal arts college!

Faster play faster faster play faster
bobdroege7 is offline   Quote this post in a PM   Nominate this post for this month's language award Copy a direct link to this post Reply With Quote Back to Top
Old 1st December 2022, 09:48 AM   #9
casebro
Penultimate Amazing
 
casebro's Avatar
 
Join Date: Jun 2005
Posts: 19,672
Originally Posted by bobdroege7 View Post
We don't talk about that on our conference calls.

Redundant analytical equipment for testing Flutemetamol, or known by its commercial name Vizamyl, is my gig. A drug used for PET scans to monitor the plaques.

Things are quiet, a dose here, a dose there, supposed to pick up soon.
[QUOTE} https://en.wikipedia.org/wiki/Flutemetamol_(18F) "Of the 176 patients imaged in this trial had a median age was 82, with 57 of patients being female. The initial flutemetamol PET scan resulted in 43 positive and 25 negative results for cerebral cortisol amyloid status." [/quote]

Looks to me that in 60% of patients results were inconclusive. Is that good enough for a test? We talk of false positive and false negative rates, but 60% inconclusive? Hmmm, that study was done in people with cognitive impairment. umm, if 60% had inconclusive amyloid levels, is amyloid the problem?
__________________
Any sufficiently advanced idea is indistinguishable from idiocy to those who don't actually understanding the concept.
casebro is offline   Quote this post in a PM   Nominate this post for this month's language award Copy a direct link to this post Reply With Quote Back to Top
Old 1st December 2022, 12:43 PM   #10
Planigale
Philosopher
 
Planigale's Avatar
 
Join Date: Jul 2013
Location: 49 North
Posts: 5,808
If you keep on testing drugs I guess by chance one will have a positive result! The disease progressed in both treatment and placebo arms. The difference in progression seemed greater in the placebo than the treatment arm. The difference was small, statistically significant, but I am not sure if it would be clinically significant. The treatment was expensive the infrastrucure to use it is significant.The side effects are significant.

I don't think this particular drug is a great breakthrough. My guess is it will be slow to be licensed in Europe.
Planigale is online now   Quote this post in a PM   Nominate this post for this month's language award Copy a direct link to this post Reply With Quote Back to Top
Old 1st December 2022, 03:53 PM   #11
lomiller
Penultimate Amazing
 
lomiller's Avatar
 
Join Date: Jul 2007
Posts: 12,671
The second line in the article

Quote:
Yet the medicine, lecanemab, has only a small effect and its impact on people's daily lives is debated.
This wouldn't be the first treatment that reduced Amyloid but had little impact on cognitive degeneration. While undoubtedly connected to the disease it doesn't look like clearing Amyloid will ever be an effective treatment.
__________________
"Anything's possible, but only a few things actually happen"
lomiller is offline   Quote this post in a PM   Nominate this post for this month's language award Copy a direct link to this post Reply With Quote Back to Top
Reply

International Skeptics Forum » General Topics » Science, Mathematics, Medicine, and Technology

Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump


All times are GMT -7. The time now is 11:01 PM.
Powered by vBulletin. Copyright ©2000 - 2023, Jelsoft Enterprises Ltd.

This forum began as part of the James Randi Education Foundation (JREF). However, the forum now exists as
an independent entity with no affiliation with or endorsement by the JREF, including the section in reference to "JREF" topics.

Disclaimer: Messages posted in the Forum are solely the opinion of their authors.