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Tags disease , prions

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Old 22nd December 2018, 01:11 AM   #1
Venom
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Cameline spongiform encephalopathy

Scientists discovered a new type of TSE in dromedary camels in Algeria earlier this year.

Quote:
We detected a prion disease in dromedary camels (Camelus dromedarius) in Algeria. Symptoms suggesting prion disease occurred in 3.1% of dromedaries brought for slaughter to the Ouargla abattoir in 2015–2016. We confirmed diagnosis by detecting pathognomonic neurodegeneration and disease-specific prion protein (PrPSc) in brain tissues from 3 symptomatic animals. Prion detection in lymphoid tissues is suggestive of the infectious nature of the disease. PrPSc biochemical characterization showed differences with BSE and scrapie. Our identification of this prion disease in a geographically widespread livestock species requires urgent enforcement of surveillance and assessment of the potential risks to human and animal health.
Very intriguing and frightening report. In particular, the hypotheses about its origin are interesting. For a few years after Britain stopped feeding meat-and-bone (MBM) to cattle in 1988 during the BSE crisis, apparently thousands of tons of the stuff was continued to be exported to the third world. Who knows where all of that hazardous waste ended up!

Then again it could be sporadic as well and we've just only now discovered it.
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Old 22nd December 2018, 03:57 AM   #2
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So no dromedary steaks for Christmas?!
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Old 22nd December 2018, 04:22 AM   #3
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Originally Posted by dann View Post
So no dromedary steaks for Christmas?!
Really? Why is this not at the top of the queue in parliamentary debate? The PM must answer questions.
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Old 22nd December 2018, 04:44 AM   #4
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Too easy to make jokes, but this indeed is a serious point. What did those damn English bastards get us into this time?
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Old 22nd December 2018, 11:11 AM   #5
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A good simple breakdown of the story here

Of course the authors didn't pursue the British MBM hypothesis too strongly cause it was beyond the scope of the study, but it'd be a great project to investigate and could win someone a Nobel Prize.
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Old 22nd December 2018, 02:29 PM   #6
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Originally Posted by Red Baron Farms View Post
Too easy to make jokes, but this indeed is a serious point. What did those damn English bastards get us into this time?
Don't you dare have a go at us English chaps, or I shall seriously get the hump with you!
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Old 22nd December 2018, 03:08 PM   #7
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Originally Posted by jonesdave116 View Post
Don't you dare have a go at us English chaps, or I shall seriously get the hump with you!
I got two words for you

Mad Cow

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Old 22nd December 2018, 03:12 PM   #8
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Originally Posted by Red Baron Farms View Post
I got two words for you

Mad Cow

How dare you! I'm not even female! Bloody cheek!
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Old 23rd December 2018, 03:58 AM   #9
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So when I posted about the appearance of a prion disease on reindeer and the consequent ban on movement of reindeer and the consequence it would have for Christmas no one was worried.
https://www.nature.com/news/deadly-a...europe-1.19759
Because it is the Three Kings' transport that is different; now royalty are affected ISF decides to have a thread.

So prion related disease has suddenly appeared in reindeer and dromedaries, or given the wide spread nature has been present undetected for many years. The reindeer are apparently infected by a widespread North American prion the puzzle is how reindeer came into contact with it. (No prize for naming the reindeer who visit north America every year.)
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Old 23rd December 2018, 04:08 AM   #10
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Originally Posted by Venom View Post
Scientists discovered a new type of TSE in dromedary camels in Algeria earlier this year.



Very intriguing and frightening report. In particular, the hypotheses about its origin are interesting. For a few years after Britain stopped feeding meat-and-bone (MBM) to cattle in 1988 during the BSE crisis, apparently thousands of tons of the stuff was continued to be exported to the third world. Who knows where all of that hazardous waste ended up!

Then again it could be sporadic as well and we've just only now discovered it.
Actually reading the paper they have pretty much excluded BSE as an origin. The PrP is completely different, and as they say cross species transmission of BSE does not result in significant changes to its chemistry. They discuss the possibility then effectively dismiss it. Scrapie would be a more likely source they say, or some other unidentified source.
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Old 23rd December 2018, 05:23 PM   #11
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TBH, I'm not sure where the idea came from that the kings would come by camel. Well, and also that they're three, or kings for that matter. Matthew just says that some wise men came from the east.

Now if they came from the West, sure, they'd have a desert to cross, but if they were coming from Mesopotamia, which makes more sense if you're going to make them some astrological validation of the Messiah, why would they need camels anyway? They're coming along a major trade route, which would have decent infrastructure. And if they're kings (which, again, Matthew doesn't say) then wouldn't they more likely come by horse?
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Old 23rd December 2018, 08:44 PM   #12
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Originally Posted by Planigale View Post
So prion related disease has suddenly appeared in reindeer and dromedaries, or given the wide spread nature has been present undetected for many years. The reindeer are apparently infected by a widespread North American prion the puzzle is how reindeer came into contact with it. (No prize for naming the reindeer who visit north America every year.)
I think it was postulated that either CWD infected hunting equipment or deer urine was exported to Europe or it arose spontaneously.

And scrapie. That scrapie origin hypothesis never goes away, even though it's never been observed.

ETA

Last edited by Venom; 23rd December 2018 at 08:50 PM.
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Old 24th December 2018, 09:38 AM   #13
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Originally Posted by Venom View Post
I think it was postulated that either CWD infected hunting equipment or deer urine was exported to Europe or it arose spontaneously.

And scrapie. That scrapie origin hypothesis never goes away, even though it's never been observed.

ETA
But wouldn't Santa use the superior 'Murican reindeer, that don't have CWD?
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Old 24th December 2018, 02:30 PM   #14
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Originally Posted by casebro View Post
But wouldn't Santa use the superior 'Murican reindeer, that don't have CWD?
No he uses use disease infected Canadian ones. Red noses and all. He tried to isolate and quarantine the sick red nosed ones, but came under heavy criticism for discrimination.
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Old 25th December 2018, 02:20 PM   #15
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Originally Posted by HansMustermann View Post
TBH, I'm not sure where the idea came from that the kings would come by camel. Well, and also that they're three, or kings for that matter. Matthew just says that some wise men came from the east.

Now if they came from the West, sure, they'd have a desert to cross, but if they were coming from Mesopotamia, which makes more sense if you're going to make them some astrological validation of the Messiah, why would they need camels anyway? They're coming along a major trade route, which would have decent infrastructure. And if they're kings (which, again, Matthew doesn't say) then wouldn't they more likely come by horse?
Hmm... Sources vary, but the only version I recall goes like this:

We three Kings,
From Orient, Ah.
One in a taxi,
One in a car.
One on a scooter,
Blowing his hooter,
Smoking a big cigar.

Which pretty much disposes of the whole "camel" thing.
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Old 25th December 2018, 07:33 PM   #16
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And if they came from the east, wouldn't they have been Khans, not kings?
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Old 25th December 2018, 07:38 PM   #17
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Originally Posted by novaphile View Post
Hmm... Sources vary, but the only version I recall goes like this:

We three Kings,
From Orient, Ah.
One in a taxi,
One in a car.
One on a scooter,
Blowing his hooter,
Smoking a big cigar.

Which pretty much disposes of the whole "camel" thing.
What do you call that rhyme scheme- Trimodal heptameter?
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Old 26th December 2018, 10:16 PM   #18
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Originally Posted by casebro View Post
And if they came from the east, wouldn't they have been Khans, not kings?
They would've been shahs.
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Old 26th December 2018, 10:52 PM   #19
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They would have been magi.
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Old 28th December 2018, 05:58 PM   #20
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Originally Posted by casebro View Post
What do you call that rhyme scheme- Trimodal heptameter?
I'm sorry, I must confess my ignorance.

The words are just something that the kids used to sing, when I was in primary school, as alternatives to the Christmas Carol "We three Kings".

We three kings of orient are
Bearing gifts we traverse afar
Field and fountain
Moor and mountain
Following yonder star
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