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Old 27th November 2020, 03:57 PM   #3201
marting
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COVID-19 Aerosolized Viral Loads, Environment, Ventilation, Masks, Exposure Time, Severity, And Immune Response: A Pragmatic Guide Of Estimates

https://icite.od.nih.gov/covid19/sea...10.03.20206110

It can be shown that over 94% of COVID-19 superspreading events occurred in limited ventilation areas suggesting that aerosolized transmission is a strong contributor to COVID-19 infections. This study helps answer the questions “How long may a person safely remain within various environments” and “What exposure levels could result in immunity without becoming ill via asymptomatic graduated inoculation”. Understanding how COVID-19 infection likelihood, symptom severity, and immune response correlate to aerosolized viral load concentration exposure levels and time durations could enable optimized Non-Pharmaceutical Interventions (NPI) that reduce severe case counts and improve at-large epidemiologic responses.
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Old 27th November 2020, 10:09 PM   #3202
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Originally Posted by dudalb View Post
Australia is doing a great job fighting thr Virus,but right now they are getting a break countries in the Northern Hemisphere don't have" It's summer down there. Current surge is largely due to the coming of cold weather.

But Australia and New Zealand have just been through Winter after spikes in cases in March/April and outside of Victoria there was almost no Community Transmission in Winter in either country. We just got to Spring and towards Summer having already done the hard yards which, as far as I can tell, nobody in Europe or the Americas ever really did. Well, not to the extent necessary anyway.



Most European countries started opening up when they were still getting hundreds of cases per day. The USA never got below 23,000. That was simply an invitation to the Virus to go forth and multiply.


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Last edited by fromdownunder; 27th November 2020 at 10:13 PM.
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Old 27th November 2020, 11:17 PM   #3203
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Covid: Free Vitamin D pills for 2.5 million vulnerable in England
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Old 27th November 2020, 11:36 PM   #3204
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I've strayed away from this forum for a few weeks, so I don't know if this has been discussed: a company in Singapore has developed a breathalyzer test that they claim gives results that are more than 90% accurate in a minute:

Quote:
The company’s test uses mass spectrometry to analyze the thousands of volatile organic compounds that people exhale with every breath, to establish a specific signal among those with an active coronavirus infection. Using a machine learning algorithm, this generates a “bio-fingerprint of COVID-19,” said co-founder and CEO Jia Zhunan.
Quote:
The NUS spinout said its ongoing pilot study of 180 people, conducted by the city-state’s National Centre for Infectious Diseases, showed an overall sensitivity of 93% and a specificity of 95%.
https://www.fiercebiotech.com/medtec...athalyzer-test
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Old Yesterday, 07:13 AM   #3205
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I have not got around to finding out all the details or discussing the mechanisms, but someone on another forum asked me "how the new vaccines work?" and I hastily put this summary of the cells and vaccines together. Do I need to correct this for those few people?

Quote:
The mRNA is delivered to the blood stream and reaches circulating immune cells, that then manufacture the viral protein.
https://en.wikipedia.org/wiki/RNA_vaccine

The viral like particles infect the number of cells in circulation that they can. They do not produce more virus or more of themselves. Once the vaccine is gone, the new immune cells produced in the bone marrow
https://en.wikipedia.org/wiki/White_blood_cell
do not get the vaccine induced spike protein.

The immune system has to learn to respond to this spike protein in the time that the vaccine particles are active and functional.
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Old Yesterday, 07:56 AM   #3206
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Originally Posted by Tero View Post
I have not got around to finding out all the details or discussing the mechanisms, but someone on another forum asked me "how the new vaccines work?" and I hastily put this summary of the cells and vaccines together. Do I need to correct this for those few people?

The Wiki text is not exactly correct. The vaccine is injected into muscle not the bloodstream. In the muscle, antigen presenting cells take up the vaccine and traffic via the lymphatic system to local lymph nodes where they present antigen to B and T cells.


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Old Yesterday, 08:24 AM   #3207
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Outcomes Related to COVID-19 Treated With Hydroxychloroquine Among Inpatients With Symptomatic Disease - ORCHID

Quote:
Study Design

Randomized
Parallel
Blinded
Placebo
No difference in outcomes found.
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Old Yesterday, 12:31 PM   #3208
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Originally Posted by Capsid View Post
The Wiki text is not exactly correct. The vaccine is injected into muscle not the bloodstream. In the muscle, antigen presenting cells take up the vaccine and traffic via the lymphatic system to local lymph nodes where they present antigen to B and T cells.

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OK. Viruses spread through the body by blood, though?
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Old Yesterday, 12:35 PM   #3209
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Not necessarily, or not entirely.
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Old Yesterday, 12:36 PM   #3210
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Originally Posted by Tero View Post
OK. Viruses spread through the body by blood, though?

Well SARS-COV-2 is viraemic in less than 5% of infected people and polio is enteric and flu etc. So no.


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Old Yesterday, 01:52 PM   #3211
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What is the mechanism that results in so much SARS-CoV-2 showing up in sewage?
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Old Yesterday, 02:55 PM   #3212
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Originally Posted by marting View Post
What is the mechanism that results in so much SARS-CoV-2 showing up in sewage?
Why wouldn't it? Hasn't human waste always been a primary mechanism of spread for all kinds of infectious disease?
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Old Yesterday, 03:20 PM   #3213
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Originally Posted by Puppycow View Post
Quelle surprise.

Misguided Use of Hydroxychloroquine for COVID-19 The Infusion of Politics Into Science
Quote:
Both patients and clinicians were desperate.

Enter hydroxychloroquine. On March 16, 2020, a study on use of hydroxychloroquine in patients with SARS-CoV-2 was “published” (online via YouTube) by Gautret et al6 (followed 4 days later as a preprint in the International Journal of Antimicrobial Agents) and purportedly demonstrated “a rapid and effective speeding up of their healing process, and a sharp decrease in the amount of time they remained contagious.”. This open-label, nonrandomized study included only 36 hospitalized patients...

However, the politicization of the treatment was a more important factor in promoting interest in use of this drug. On April 4, the US president, “speaking on gut instinct,” promoted the drug as a potential treatment and authorized the US government to purchase and stockpile 29 million pills of hydroxychloroquine for use by patients with COVID-19...

But science doesn't let politics steamroll over it that easily...

Quote:
US health officials, such as members of the Coronavirus Task Force, leaders from the National Institutes of Health, and officers of physician organizations and societies, who resisted being forced to promote the politically motivated use of hydroxychloroquine were correct and should be recognized for their steadfast commitment to science...

The clear, unambiguous, and compelling lesson from the hydroxychloroquine story for the medical community and the public is that science and politics do not mix. Science, by definition, requires diligence and an honest assessment of findings; politics not so much. The number of articles in the peer-reviewed literature over the last several months that have consistently and convincingly demonstrated the lack of efficacy of a highly hyped “cure” for COVID-19 represent the consequence of the irresponsible infusion of politics into the world of scientific evidence and discourse.
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Old Yesterday, 03:34 PM   #3214
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Originally Posted by marting View Post
What is the mechanism that results in so much SARS-CoV-2 showing up in sewage?
Even with 30 days of zero infections in Victoria Australia, traces still show up in sewage in a couple of places. Our experts believe this is due to shedding from people who were infected weeks ago and there is no chance of infection.
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Old Yesterday, 11:24 PM   #3215
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New review of 4 Ivermectin studies shows promise.

https://icite.od.nih.gov/covid19/sea...ordId=33227231

Abstract:
The current management of COVID-19 is mostly limited to general supportive care and symptomatic treatment. Ivermectin is a broad-spectrum anti-parasitic drug used widely for the treatment of onchocerciasis and lymphatic filariasis. Apart from its anti-parasitic effect it also exhibits antiviral activity against a number of viruses both in vitro and in vivo. Hence, we conducted this systematic review and meta-analysis to assess the currently available data on the therapeutic potential of ivermectin for the treatment of COVID-19 as add on therapy. A total of 629 patients were included in the 4 studies and all were COVID-19 RT-PCR positive. Among them, 397 patients received ivermectin along with usual therapy. The random effect model showed the overall pooled OR to be 0.53 (95%CI: 0.29 to0.96) for the primary outcome (all-cause mortality) which was statistically significant (P=0.04). Similarly, the random effect model revealed that adding ivermectin led to significant clinical improvement compared to usual therapy (OR=1.98, 95% CI: 1.11 to 3.53, P=0.02). However, this should be inferred cautiously as the quality of evidence is very low. Currently, many clinical trials are on-going, and definitive evidence for repurposing this drug for COVID-19 patients will emerge only in the future.
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Old Yesterday, 11:34 PM   #3216
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Another Ivermectin study. Small randomized clinical trial but with rather strong positive benefits.

https://icite.od.nih.gov/covid19/sea...rdId=rs-109670

Ivermectin as an adjunct treatment for hospitalized adult COVID-19 patients: A randomized multi-center clinical trial

Abstract
Background: It appears that ivermectin can potentially act against COVID-19 infection. Today, it is an urgent need to evaluate the efficacy and safety of ivermectin. The effect of ivermectin therapy on mild to severe COVID-19 patients was investigated.

Methods: A 45-days randomized, double-blind, placebo-controlled, multicenter, phase 2 clinical trial was designed at five hospitals. A total number of 180 mild to severe hospitalized patients with confirmed PCR and chest image tests were enrolled. The radiographic findings, hospitalization and low O2 saturation duration, and clinical outcomes such as mortality and variables of blood samples were analyzed using standard statistical analyses in SPSS (V20).

Results: Average age of the participants was 56 years (45-67) and 50% were women. The primary and secondary results showed significant changes between day zero and day five of admission (∆ 0/5) in terms of ΔALC5/0, ΔPLT5/0, ΔESR5/0, ΔCRP5/0, duration of low O2 saturation, and duration of hospitalization (CI = 95% ). Risk of mortality was also decreased significantly in the study groups.

Conclusion: Ivermectin as an adjunct reduced the rate of mortality, low O2 duration, and duration of hospitalization in adult COVID 19 patients. The improvement of other clinical parameters showed that the ivermectin, with a wide margin of safety, had a high therapeutic effect on COVID-19.
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Old Yesterday, 11:40 PM   #3217
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Originally Posted by marting View Post
Another Ivermectin study. Small randomized clinical trial but with rather strong positive benefits.
That's more excellent news.

A little ironic the HCQ people were on the right track with an anti-parasitic drug, just the wrong one. And a much safer one!
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Old Today, 01:06 AM   #3218
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Dr Mobeen Syed (whose video on Vitamin D I posted quite a while back) posted another video about Ivermectin.

https://www.youtube.com/watch?v=JEO7Adv3tVI

YouTube Video This video is not hosted by the ISF. The ISF can not be held responsible for the suitability or legality of this material. By clicking the link below you agree to view content from an external website.
I AGREE


This one's about how Ivermectin helps against SARS-COV-2 via its

De-worming mechanism and cellular effect (@ 7:40)
Antiviral effect (@ 13 min) (it occupies the importins so the virus can't enter the nuclei and the cell can release interferons)
Antiinflammatory mechanism (@ 18.22).
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Old Today, 01:07 AM   #3219
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Dr Mobeen Syed (whose video on Vitamin D I posted quite a while back) posted another video about Ivermectin.

https://www.youtube.com/watch?v=JEO7Adv3tVI

YouTube Video This video is not hosted by the ISF. The ISF can not be held responsible for the suitability or legality of this material. By clicking the link below you agree to view content from an external website.
I AGREE


This one's about how Ivermectin helps against SARS-COV-2 via its

-De-worming mechanism and cellular effect (@ 7:40)

-Antiviral effect (@ 13 min) (it occupies the importins so the virus can't enter the nuclei and the cell can release interferons)

-Anti-inflammatory mechanism (@ 18.22).
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Old Today, 09:01 PM   #3220
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Addressing again how COVID 19 is spread.

From the Sweden thread:
Originally Posted by Rolfe View Post
Yes, they're describing aerosol transmission indoors, and "long distances or times" is a relative term. True airborne transmission where the bloody thing blows on the wind and can be caught hundreds of metres away downwind in the open air is thankfully not an issue with this one.
That is simply not true. Tuberculosis is airborne yet you won't catch it outside in the wind. You have to breathe in a concentrated amount of droplet nuclei (not to be confused with droplets in droplet spread) in order for enough of the TB bacillus to make it to the alveoli which has the conditions it requires to start an infection.

More than a few professionals who should know better are still unwilling to call COVID airborne. They bought into the droplet spread the same way some of them bought into no asymptomatic spread and they just can't let go.

They took my temperature today at the clinic I went to for an MRI. Even the bank had sense enough to ask some standard questions about one's potential exposure before they let me in. But clinics and the airport are still screening people for fever like this was SARS 1 and fever was a reliable means of screening people. Not to mention I take acetaminophen every day for chronic pain. It would mask a fever if I had one. No one who has taken my temperature has asked if I were on any antipyretics.

And now here we are again ignoring the science that has documented COVID 19 being airborne spread. Instead of going by the science, people are clinging to their initial information that it was droplet spread.

Use caution interpreting all those guidelines that ignore airborne spread or papers that simply say 'some airborne but only sometimes'. Pathogens can be airborne and droplet spread. They need not be one or the other.

Tuberculosis for anyone curious is never droplet spread. Put it on your hands and into your mouth and it won't grow.

Now you can get TB when it is aerosolized by the bone saw in surgery or in an autopsy. And you can get it from a dirty needle in which case it develops an abscess. But you probably won't get miliary TB (disseminated) by using a dirty needle. The number of organisms injected are too few to really get a start.

My point is, pathogens do not always fall neatly into the categories we put them in. COVID 19 is droplet spread and airborne. There is no reason to fuss over it. I can't imagine putting up an isolation sign on a patient's room that said: DROPLET PRECAUTIONS and sometimes AIRBORNE PRECAUTIONS. See the nurses for an explanation.

The same with teaching or recommending isolation policy, it's not useful if I had to say droplet spread then go into a paragraph long caveat.

It is droplet spread and yes, it is also airborne. And if our CDC hadn't been trashed by having the leadership (including Fauci) completely politicized, it wouldn't even be an issue. It would have been designated airborne and droplet spread last March which is when I read the first reports that it was clearly airborne.
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